By bus
Greyhound Bus Lines serves the Palmdale Transportation Center daily.
The Antelope Valley Transit Authority AVTA has daily commuter bus lines that connect to the Palmdale Transportation Center from various areas in Los Angeles. The AVTA is also the operator of the city's public bus system.
Santa Clarita Transit has a daily commuter bus line that runs to the Palmdale Transportation Center from the nearby city of Santa Clarita.
By plane
Palmdale Regional Airport IATA: PMD was served by United Airlines, but currently has no scheduled service.
The next closest airport is Bob Hope Airport IATA: BUR in Burbank, approximately one hour's drive to the South, and is served by most major carriers except Northwest & Continental.
Los Angeles International Airport IATA: LAX, Ontario International Airport IATA: ONT, and Bakersfield Meadows Field IATA: BFL are all approximately the same distance away timewise, assuming no traffic.
LAX has the most travel options and is generally the least expensive, but is significantly crowded and has many a long line in addition to the excessive traffic one must usually contend with to get to/from the airport.
Ontario will be much less crowded and easier to use. Traffic can be bad at times, but not nearly as bad as LAX.
Bakersfield is also an easy to use, uncrowded airport like Ontario, but has less flight options and is also generally more expensive, however, there is little to no traffic problems reaching BFL.
If you are willing to drive really far 90-120 miles, Long Beach Municipal Airport IATA: LGB and John Wayne International IATA: SNA may also be used as alternates.
There are a couple of Shuttle Bus companies that operate daily from Palmdale to LAX, costing approximately $70 one way:
Antelope Valley Airport Express
+1 661 945-2529.On Time Airport Super Shuttle
+1 800 372-3372.
By train
The Palmdale Transportation Center in downtown, has daily rail service to Los Angeles area destinations via Metrolink, a commuter rail line. The center is also served by Amtrak California, the national passenger rail carrier, using it's Thruway Bus service. It is the metropolitan area's mass-transit hub.
The Vincent-Grade/Acton Metrolink station serves southern Palmdale and nearby Acton with commuter rail service to/from Los Angeles.
Other than coming to or leaving town, rail service is not particularly used in this area as there are only 2 stations serving Palmdale and 1 more in nearby Lancaster.
By car
Palmdale is about 70 miles north of Downtown Los Angeles off of California State Highway 14, the Antelope Valley Freeway. The A.V. Freeway is the area's principal NORTH - SOUTH route. The other end of CA-14 to the North connects Reno, Nevada to the Palmdale area via US Highway 395.
California State Highway 138 is the principal EAST - WEST route and connects the Inland Empire Riverside-San Bernardino-Ontario and the "Grapevine" area of Interstate 5 to the Palmdale area.
California State Highway 18 connects the Victor Valley area to the Palmdale area via CA-138.